ORCID

0000-0002-2240-4298

Department

Biological Sciences

Year of Study

1

Full-time or Part-time Study

Full-time

Level

Postgraduate

Name of Course

Genomic Data Science

Presentation Type

Poster

Supervisor

Prof Douwe van Sinderen

Supervisor

Dr Francesca Bottacini

Abstract

A wide variety of microorganisms, including bifidobacteria, are known to colonise the human gastrointestinal tract. Bifidobacteria are beneficial bacteria known to be particularly prevalent and abundant in the gut of healthy and breast-fed infants. Together with bacteria, bacteriophages can be vertically transmitted from mother to newborn during vaginal delivery and they are believed to play a role in influencing bacterial levels and microbiota composition in early in life. While there is a significant amount of information on early bacterial colonisers in the infant gut, there is currently very limited knowledge of diversity and prevalence of gut bacteriophages and their impact on the early microbiota composition. The work here presented gives an overview of current methods suitable for the study of metagenomes and viromes in infant fecal samples. By evaluating a range of bioinformatic tools a new analysis pipeline was developed for future application in the analysis and characterisation of phage diversity and host interaction in the early gut microbiota.

Keywords:

microbiome, virome

Start Date

2-11-2023 11:15 AM

End Date

2-11-2023 12:00 PM

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Nov 2nd, 11:15 AM Nov 2nd, 12:00 PM

Microbiome and virome analysis in early life

A wide variety of microorganisms, including bifidobacteria, are known to colonise the human gastrointestinal tract. Bifidobacteria are beneficial bacteria known to be particularly prevalent and abundant in the gut of healthy and breast-fed infants. Together with bacteria, bacteriophages can be vertically transmitted from mother to newborn during vaginal delivery and they are believed to play a role in influencing bacterial levels and microbiota composition in early in life. While there is a significant amount of information on early bacterial colonisers in the infant gut, there is currently very limited knowledge of diversity and prevalence of gut bacteriophages and their impact on the early microbiota composition. The work here presented gives an overview of current methods suitable for the study of metagenomes and viromes in infant fecal samples. By evaluating a range of bioinformatic tools a new analysis pipeline was developed for future application in the analysis and characterisation of phage diversity and host interaction in the early gut microbiota.