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Biochemistry | Biochemistry, Biophysics, and Structural Biology | Biology | Genetics and Genomics
An overwhelming array of structural variants has evolved from a comparatively small number of protein structural domains; which has in turn facilitated an expanse of functional derivatives. Herein, I review the primary mechanisms which have contributed to the vastness of our existing, and expanding, protein repertoires. Protein function prediction strategies, both sequence and structure based, are also discussed and their associated strengths and weaknesses assessed.
Sleator, R.D. (2012). Proteins. Bioengineered, [online] 3(2), pp.80–85. Available at: https://www.tandfonline.com/doi/full/10.4161/bbug.18303