Authors

Roy D. Sleator

Document Type

Article

Creative Commons License

Creative Commons Attribution 4.0 License
This work is licensed under a Creative Commons Attribution 4.0 License.

Disciplines

Biochemistry | Biochemistry, Biophysics, and Structural Biology | Biology | Genetics and Genomics

CIT Disciplines

1.6 BIOLOGICAL SCIENCES; Cell biology,; Biochemistry and molecular biology; Genetics and heredity

Publication Details

Bioengineered

Abstract

An overwhelming array of structural variants has evolved from a comparatively small number of protein structural domains; which has in turn facilitated an expanse of functional derivatives. Herein, I review the primary mechanisms which have contributed to the vastness of our existing, and expanding, protein repertoires. Protein function prediction strategies, both sequence and structure based, are also discussed and their associated strengths and weaknesses assessed.

Share

COinS