Document Type
Article
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Disciplines
Biology | Life Sciences | Microbiology
Abstract
Lactoferrin is an antimicrobial glycoprotein that demonstrates a broad-spectrum of activity against a wide variety of clinical pathogens. This study investigated the potential of bovine lactoferrin (bLf) against multidrug resistant Staphylococcus capitis (S. capitis) strains. Growth curve analysis and time-kill curves demonstrated that at 750 µg ml−1 lactoferrin significantly inhibited (50.6%, P < 0.05) the growth of most isolates tested (90%), and this effect was based on a bacteriostatic mechanism. At the same concentration, bLf also significantly inhibited (30%, P < 0.05) biofilm formation in 40% of strains tested. Combinations of bLf with selected antibiotics were assessed for enhanced antimicrobial activity using growth curves. BLf combined with β-lactam antibiotics reduced the growth of S. capitis strains, however, the effects were not significant. BLf displays antimicrobial effects against multidrug resistant S. capitis isolates, but with strain-specific effects.
Recommended Citation
Anna Desmond, Lesley Cotter, Des Field, Fiona O'Halloran, Investigating the antimicrobial potential of bovine lactoferrin against the neonatal pathogen, Staphylococcus capitis, Letters in Applied Microbiology, Volume 77, Issue 7, July 2024, ovae068, https://doi.org/10.1093/lambio/ovae068
Publication Details
Letters in Applied Microbiology, vol. 77, no. 7. © The Author(s) 2024.