Phage lysin LysK can be truncated to its CHAP domain and retain lytic activity against live antibiotic-resistant staphylococci

Authors

Marianne Horgan, Moorepark Food Research Centre
Gary O'Flynn, Moorepark Food Research Centre
Jennifer Garry, Moorepark Food Research Centre
Jakki Cooney, University of Limerick
Aidan Coffey, Department of Biological Sciences, Cork Institute of Technology, Cork, IrelandFollow
Gerald F. Fitzgerald, University College Cork
R. Paul Ross, Moorepark Food Research Centre
Olivia McAuliffe, Moorepark Food Research Centre

Document Type

Article

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Disciplines

Biology

Publication Details

Applied and Environmental Microbiology

Abstract

A truncated derivative of the phage endolysin LysK containing only the CHAP (cysteine- and histidine-dependent amidohydrolase/peptidase) domain exhibited lytic activity against live clinical staphylococcal isolates, including methicillin-resistant Staphylococcus aureus. This is the first known report of a truncated phage lysin which retains high lytic activity against live staphylococcal cells. Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Recommended Citation

Horgan, Marianne; O'Flynn, Gary; Garry, Jennifer; Cooney, Jakki; Coffey, Aidan; Fitzgerald, Gerald F.; Paul Ross, R.; and McAuliffe, Olivia, "Phage lysin LysK can be truncated to its CHAP domain and retain lytic activity against live antibiotic-resistant staphylococci" (2009). Department of Biological Sciences Publications [online].
Available at: https://doi.org/10.1128/AEM.01831-08