Date of Award
2008
Document Type
Master Thesis
Degree Name
Masters of Science (Research)
Department
Biological Sciences
First Advisor
Carolyn Holt
Second Advisor
Patricia Kennedy
Abstract
People with type II diabetes are disproportionately affected by cardiovascular disease compared to those without diabetes. The relative risk of cardiovascular disease caused by type II diabetes is higher in females than in males. This risk has not been fully explained by traditional risk factors and attention has turned to the possible role of haemostatic abnormalities in explaining the excess cardiovascular morbidity and mortality among diabetic females. We examined specific parameters of the coagulation (factor VII, factor VIII, von Willebrand factor, fibrinogen) and fibrinolytic (plasminogen activator inhibitor- 1, thrombin-activatable fibrinolysis inhibitor) system in 113 Irish Caucasian type II diabetics to determine if these parameters possibly contribute to the increased risk of cardiovascular disease in diabetic females. This study demonstrated the prothrombotic state of type II diabetes with increased levels of factor VII (111.0 versus 100%, P
Recommended Citation
Quirke, William, "Gender Bias of Cardiovascular Risk in Caucasian Type II Diabetics: A Haemostatic Explanation?" (2008). Theses [online].
Available at: https://sword.cit.ie/allthe/202
Access Level
info:eu-repo/semantics/openAccess
Included in
Biochemical Phenomena, Metabolism, and Nutrition Commons, Biochemistry Commons, Circulatory and Respiratory Physiology Commons