Selection of potential therapeutic bacteriophages that lyse a CTX-M-15 extended spectrum β-lactamase producing Salmonella enterica serovar typhi strain from the democratic republic of the Congo

Authors

Elene Kakabadze, Ivane Javakhishvili Tbilisi State University
Khatuna Makalatia, Ivane Javakhishvili Tbilisi State University
Nino Grdzelishvili, Ivane Javakhishvili Tbilisi State University
Nata Bakuradze, Ivane Javakhishvili Tbilisi State University
Marina Goderdzishvili, Ivane Javakhishvili Tbilisi State University
Ia Kusradze, Ivane Javakhishvili Tbilisi State University
Marie France Phoba, University Teaching Hospital of Kinshasa
Octavie Lunguya, University Teaching Hospital of Kinshasa
Cédric Lood, KU Leuven
Rob Lavigne, KU Leuven
Jan Jacobs, Prins Leopold Instituut voor Tropische Geneeskunde
Stijn Deborggraeve, Prins Leopold Instituut voor Tropische Geneeskunde
Tessa De Block, Prins Leopold Instituut voor Tropische Geneeskunde
Sandra Van Puyvelde, Prins Leopold Instituut voor Tropische Geneeskunde
David Lee, Cork Institute of Technology
Aidan Coffey, Department of Biological Sciences, Cork Institute of Technology, Cork, IrelandFollow
Anahit Sedrakyan, Institute of Molecular Biology of the National Academy of Sciences of Armenia
Patrick Soentjens, Prins Leopold Instituut voor Tropische Geneeskunde
Daniel De Vos, Queen Astrid Military Hospital
Jean Paul Pirnay, Queen Astrid Military Hospital
Nina Chanishvili, Ivane Javakhishvili Tbilisi State University

Document Type

Article

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Disciplines

Biology

Publication Details

Viruses

Abstract

© 2018 by the authors. Licensee MDPI, Basel, Switzerland. Recently, a Salmonella Typhi isolate producing CTX-M-15 extended spectrum β-lactamase (ESBL) and with decreased ciprofloxacin susceptibility was isolated in the Democratic Republic of the Congo. We have selected bacteriophages that show strong lytic activity against this isolate and have potential for phage-based treatment of S. Typhi, and Salmonella in general.

Recommended Citation

Kakabadze, E.; Makalatia, K.; Grdzelishvili, N.; Bakuradze, N.; Goderdzishvili, M.; Kusradze, I.; Phoba, M.-F.; Lunguya, O.; Lood, C.; Lavigne, R.; Jacobs, J.; Deborggraeve, S.; De Block, T.; Van Puyvelde, S.; Lee, D.; Coffey, A.; Sedrakyan, A.; Soentjens, P.; De Vos, D.; Pirnay, J.-P.; Chanishvili, N. Selection of Potential Therapeutic Bacteriophages that Lyse a CTX-M-15 Extended Spectrum β-Lactamase Producing Salmonella enterica Serovar Typhi Strain from the Democratic Republic of the Congo. Viruses 2018, 10, 172.