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Biology | Life Sciences
A key phenotypic characteristic of the Gram-positive bacterial pathogen, Staphylococcus aureus, is its ability to grow in low aw environments. A homology transfer based approach, using the well characterised osmotic stress response systems of Bacillus subtilis and Escherichia coli, was used to identify putative osmotolerance loci in Staphylococcus aureus ST772-MRSA-V. A total of 17 distinct putative hyper and hypo-osmotic stress response systems, comprising 78 genes, were identified. The ST772-MRSA-V genome exhibits significant degeneracy in terms of the osmotic stress response; with three copies of opuD, two copies each of nhaK and mrp/mnh, and five copies of opp. Furthermore, regulation of osmotolerance in ST772-MRSA-V appears to be mediated at the transcriptional, translational, and post-translational levels.
Dylan Casey, Roy D. Sleator, A genomic analysis of osmotolerance in Staphylococcus aureus, Gene, 2020,145268, ISSN 0378-1119, https://doi.org/10.1016/j.gene.2020.145268. (http://www.sciencedirect.com/science/article/pii/S0378111920309379)