Title

Bacteriophage-derived peptidase CHAPK eliminates and prevents staphylococcal biofilms

Document Type

Article

Disciplines

Biology

Publication Details

International Journal of Microbiology

Abstract

New antibacterial agents are urgently needed for the elimination of biofilm-forming bacteria that are highly resistant to traditional antimicrobial agents. Proliferation of such bacteria can lead to significant economic losses in the agri-food sector. This study demonstrates the potential of the bacteriophage-derived peptidase, CHAP K, as a biocidal agent for the rapid disruption of biofilm-forming staphylococci, commonly associated with bovine mastitis. Purified CHAP K applied to biofilms of Staphylococcus aureus DPC5246 completely eliminated the staphylococcal biofilms within 4 h. In addition, CHAP K was able to prevent biofilm formation by this strain. The CHAP K lysin also reduced S. aureus in a skin decolonization model. Our data demonstrates the potential of CHAP K as a biocidal agent for prevention and treatment of biofilm-associated staphylococcal infections or as a decontaminating agent in the food and healthcare sectors. © 2013 Mark Fenton et al.

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