Date of Award


Document Type

Doctoral Thesis

Degree Name

Doctor of Philosophy


Biological Sciences

First Advisor

Dr Máire Begley

Second Advisor

Dr Des Field


Bacteriocins are a diverse range of ribosomally synthesized bioactive peptides, recognised predominantly for their potent antimicrobial activity against other strains closely related to the producer. The focus of this thesis was to explore this activity and examine the potential of bacteriocins to inhibit the growth of clinically relevant pathogens. Although evidence exists in the literature to suggest that bacteriocins could be applied in a similar fashion to conventional antibiotics, to date they are only utilised as preservative in food to prevent the growth of foodborne illness causing organisms. Isolating and screening bacterial strains in order to identify bacteriocin producers has led to the successful identification and characterisation of peptides which appear to inhibit the growth of a variety of pathogens responsible for illness in humans. This thesis looked to identify bacteriocins with the potential to inhibit members of the Staphylococcus genus, particularly methicillin resistant Staphylococcus aureus (MRSA) given its prevalence and the threat it poses in nosocomial settings.

Creative Commons License

Creative Commons Attribution 4.0 International License
This work is licensed under a Creative Commons Attribution 4.0 International License.

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